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Details
E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease.
E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro.
By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer's disease animal models.
Catalog Number
N-1650
Synonyms
E-64d, Aloxistatin, L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, EP453, Loxistatin
Molecular Formula
C₁₇H₃₀N₂O₅
Relative Molecular Mass
342.44
CAS Registry Number
88321-09-9
Storage Conditions
-20 ± 5 °C
Keywords
Cell-permeable Cys proteinase inhibitor
Application
Alzheimer's Disease
Links / Documents:
Bachem product citations
A.Bervar et al.,
Radiology and oncology,
2,
169 (2002)
4027911
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Cathepsin H | ||
| Calpain | ||
| Cathepsin D | ||
| Cathepsin L | ||
| Calpain-2 | ||
| Cathepsin B |
