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Details
Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.
Catalog Number
H-4012
One Letter Code
EGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH₂
Synonyms
Glucagon-Like Peptide 1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat), Preproglucagon (100-127) amide (human, bovine, guinea pig, mouse, porcine, rat), Proglucagon (80-107) amide (human, bovine, guinea pig, mouse, porcine, rat)
Molecular Formula
C₁₄₀H₂₁₄N₃₆O₄₃
Relative Molecular Mass
3089.46
CAS Registry Number
161748-29-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Major metabolite of GLP-1
Application
Diabetes
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