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Availability: In stock


4027537

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4027537.0001 1 Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 73.00
CHF 67.89 (7%)
4027537.0005 5 Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 189.00
CHF 175.77 (7%)

Details

Substrate for the determination of E.coli dihydroorotase (EC 3.5.2.3.), which catalyzes the cyclization of carbamoyl-Asp-OH into L-5,6-dihydroorotate. This enzyme being in the biosynthetic pathway of pyrimidine nucleotides, is an important therapeutic target for the design of new antineoplastic agents. Its activity was assayed spectrophotometrically measuring the increase of absorbance at 230 nm (ε₂₃₀ = 1170 M⁻¹cm⁻¹, Km = 0.47 mM, kcat = 143 s⁻¹).