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Availability: In stock

Z-Leu-Leu-4,5-dehydro-Leu-aldehyde

4027531

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4027531.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 105.00
CHF 97.65 (7%)
4027531.0005 5 mg Ships within 3-5 business days  
CHF 420.00
CHF 390.60 (7%)
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Details

The peptide aldehyde SIB1281 inhibited the formation of β- and γ-secretase derived amyloid β-protein (Aβ) with IC₅₀ = 1.8 µM and stimulated the formation of α-secretase derived soluble amyloid precursor protein (sα) with an EC₅₀ of 250 nM.
Catalog Number N-1590
APC Number 81-5-17
Synonyms SIB 1281, Z-Leu-Leu-4,5-dehydro-Leu-CHO
Molecular Formula C₂₆H₃₉N₃O₅
Relative Molecular Mass 473.61
CAS Registry Number [181139-85-5]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

Product citations

I.A.McDonald et al., 212th ACS Natl. Meeting, Orlando, Florida, USA, August 25-29, 1996; Derwent Conf. Fast-Track, 4 (12), 81 (1996)

4027531

Enzyme Substrates Inhibitors
γ-Secretase    
β-Secretase