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Details
The Nε-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of lysine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.
Catalog Number
B-3015
Molecular Formula
C₃₁H₃₆N₂O₆
Relative Molecular Mass
532.64
CAS Registry Number
150629-67-7
Storage Conditions
-20 ± 5 °C
Links / Documents:
Product citations
R.A.Kramer and W.Bannwarth,
Helv. Chim. Acta,
92,
1046 (2009)
W.C.Chan et al.,
J. Chem. Soc. Chem. Commun.,
2209 (1995)
