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Details
Z-Phe-Tyrosinal is a potent and selective cathepsin L inhibitor. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.
Catalog Number
N-1540
APC Number
32-5-02
Synonyms
Z-FY-CHO, Cathepsin-L Inhibitor
Molecular Formula
C₂₆H₂₆N₂O₅
Relative Molecular Mass
446.50
CAS Registry Number
[167498-29-5]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Cathepsin L inhibitor
Areas of Interest
Osteoporosis Research
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Bachem product citations
4027130
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Cathepsin B | ||
| Cathepsin L | ||
| Calpain |
