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4026865

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Z-Val-Ala-DL-Asp-fluoromethylketone

4026865

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4026865.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
4026865.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,261.00
CHF 1,172.73 (7%)

Details

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis. Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560. Inhibitor of peptide:N-glycanase (PNGase).
Catalog Number N-1510
Synonyms Z-VAD-FMK
Molecular Formula C₂₁H₂₈FN₃O₇
Relative Molecular Mass 453.47
CAS Registry Number 220644-02-0
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Pan-caspase inhibitor
Application Apoptosis & Necrosis
Cancer Research
Links / Documents:
Brochures:

Bachem product citations

M.Yamaguchi et al., International Journal of Oral-Medical Sciences, 16, 31 (2017)
C.Lawlor et al., PLoS One, 11, e0149167 (2016)
L.Kinzel et al., Oncotarget, 7, 43199 (2016)
M.H.Bashari et al., Breast Cancer Res., 18, 26 (2016)
M.Schirmer et al., Cell Death Dis., 7, e2052 (2016)
V.Zoller et al., Cell Death Dis., 7, e2412 (2016)
S.B.Berger et al., Cell Death Discov., 1, 15009 (2015)
B.B.Manshian et al., Sci. Rep., 5, 13890 (2015)
C.D.Lucas et al., Am. J. Respir. Crit. Care Med., 191, 626 (2015)
J.M.Gajer et al., Oncogenesis, 4, e137 (2015)
L.Y.Chiu et al., PLoS One, 10, e0125774 (2015)
M.F.Brown et al., Cell Death Dis., 6, e1729 (2015)
M.Fares et al., Biochem. Biophys. Res. Commun., 463, 268 (2015)
M.Najjar et al., Cell. Rep., 10, 1850 (2015)
N.Echeverry et al., Cell Death Dis., 6, e1757 (2015)
P.Geserick et al., Cell. Death Dis., 6, e1884 (2015)
S.Cristofanon et al., Cell Death Dis., 6, e1724 (2015)
U.Cersosimo et al., J. Med. Chem., 58, 1691 (2015)
Z.Baranski et al., Oncotarget, 6, 36113 (2015)
A.Degterev et al., Methods Enzymol., 545, 1 (2014)
A.M.Pedersen et al., Int. J. Oncol., 45, 2167 (2014)
A.Weilbacher et al., Cell Death Dis., 5, e1318 (2014)
C.J.Kearney et al., FEBS J., 281, 4921 (2014)
D.Lissa et al., Proc. Natl. Acad. Sci. USA, 111, 3020 (2014)
E.Hollville et al., Mol. Cell, 55, 451 (2014)
F.A.Abulwerdi et al., J. Med. Chem., 57, 4111 (2014)
F.De Nicola et al., Cell Death Dis., 5, e1414 (2014)
G.Perez-Chacon et al., Pharmacol. Res., 89, 46 (2014)
H.Song et al., PLoS One, 9, e114457 (2014)
K.E.McCabe et al., Cell Death Dis., 5, e1496 (2014)
M.Ehrenschwender et al., Cell Death Dis., 5, e1570 (2014)
Q.Remijsen et al., Cell Death Dis., 5, e1004 (2014)
R.G.Carroll et al., Cell. Rep., 9, 1538 (2014)
W.C.Lin et al., Cell Death Dis., 5, e1109 (2014)
W.C.Lin et al., Cell Death Dis., 5, e1109 (2014)
Y.Estornes et al., Cell Death Dis., 5, e1555 (2014)
A.C.Vion et al., Pulm. Circ., 3, 95 (2013)
C.A.Patwardhan et al., J. Biol. Chem., 288, 7313 (2013)
C.Friesen et al., Oncotarget, 4, 677 (2013)
C.Friesen et al., Eur. J. Cancer, 49, 2542 (2013)
C.Gallerne et al., Biochim. Biophys. Acta, 1833, 1356 (2013)
C.R.McNamara et al., PLoS One, 8, e56576 (2013)
C.Seitz et al., Int. J. Cancer, 132, 2682 (2013)
E.Preuss et al., J. Biol. Chem., 288, 35287 (2013)
F.Basit et al., Cell Death Differ, 20, 1161 (2013)
F.Rapino et al., Cell Death Dis., 4, e925 (2013)
J.Sosna et al., Cell Commun. Signal, 11, 76 (2013)
K.Demeyere et al., Vet. Immunol. Immunopathol., 153, 45 (2013)
L.Steinhart et al., Cell Death Dis., 4, e802 (2013)
L.Vela et al., J. Biol. Chem., 288, 4935 (2013)
N.Syed et al., Cell Death Dis., 4, e458 (2013)
R.Weiss et al., Cell Death Dis., 20, 823 (2013)
S.P.Cullen et al., Mol. Cell, 49, 1034 (2013)
S.Y.Yang et al., Evid. Based Complement. Alternat. Med., 2013, 630415 (2013)
A.Rodriguez-Enfedaque et al., Biochim. Biophys. Acta, 1823, 1343 (2012)
A.Spes et al., Biol. Chem., 393, 1417 (2012)
D.Kogel et al., Neurobiol. Aging, 33, 2200 (2012)
F.Basit et al., J. Biol. Chem., 287, 38767 (2012)
F.Bensassi et al., Food Chem. Toxicol., 50, 1680 (2012)
F.Bensassi et al., Toxicol. In Vitro, 26, 915 (2012)
J.I.Aguilo et al., Chem. Biol. Interact., 198, 18 (2012)
L.Duprez et al., J. Biol. Chem., 287, 14863 (2012)
L.Verschooten et al., PLoS One, 7, e48264 (2012)
M.J.Ruiz-Magana et al., Int. J. Cancer, 130, 1195 (2012)
M.Jemaa et al., Cell Cycle, 11, 2149 (2012)
M.Jemaa et al., EMBO Mol. Med., 4, 500 (2012)
O.Sharaf el dein et al., Biochem. Pharmacol., 83, 1172 (2012)
R.Martin-Perez et al., Apoptosis, 17, 349 (2012)
R.W.Rooswinkel et al., Cell Death Dis., 3, e366 (2012)
T.Sun et al., Front. Mol. Neurosci., 5, 93 (2012)
Z.Wang et al., Cell, 148, 228 (2012)
X.S.Sun et al., J. Cancer Ther., 2, 418 (2011)
A.S.Michallet et al., PLoS One, 6, e25820 (2011)
B.Laukens et al., Neoplasia, 13, 971 (2011)
C.Bedia et al., J. Biol. Chem., 286, 28200 (2011)
D.Stadel et al., Neoplasia, 13, 1162 (2011)
F.Bensassi et al., Toxicology, 290, 230 (2011)
G.Polier et al., Cell Death Dis., 2, e182 (2011)
J.Balart et al., Radiat Oncol, 6, 6 (2011)
J.G.Christian et al., PLoS Pathog., 7, e1002283 (2011)
J.Rudner et al., Biochem. Pharmacol., 81, 32 (2011)
L.Fredriksson et al., Hepatology, 53, 2027 (2011)
L.Vela et al., J. Inorg. Biochem., 105, 1306 (2011)
M.Feoktistova et al., Mol. Cell., 43, 449 (2011)
N.Badiola et al., Cell Death Dis., 2, e149 (2011)
R.T.Lima et al., J. Cell. Biochem., 112, 200 (2011)
Y.M.Wang et al., Bone, 48, 1336 (2011)
M.S.I.Abaza, Exp. Ther. Med, 1, 675 (2010)
J.Rudner et al., Biochem. Pharmacol., 79, 10 (2010)
N.Le Floch et al., Biochem. Biophys. Res. Commun., 399, 173 (2010)
S.Solier and Y.Pommier, Cancer Res., 71, 906 (2010)
S.Ussat et al., Scand. J. Immunol., 72, 388 (2010)
A.U.Luthi et al., Immunity, 31, 84 (2009)
D.Fuchs et al., Biochem. Biophys. Res. Commun., 390, 743 (2009)
G.D.Maurer et al., Neuro Oncol., 11, 747 (2009)
G.D.Maurer et al., Neuro. Oncol., 11, 747 (2009)
G.O'Sullivan-Coyne et al., Br. J. Cancer, 101, 1585 (2009)
J.C.Puigvert et al., Mol. Pharmacol., 75, 947 (2009)
L.Castera et al., J. Cell Mol. Med., 13, 1321 (2009)
M.Klaric et al., Biochim. Biophys. Acta, 1794, 1372 (2009)
O.Kepp et al., PLoS Pathog., 5, e1000348 (2009)
R.Alonso et al., Blood, 114, 1563 (2009)
R.Calafell et al., Eur. J. Pharmacol., 610, 128 (2009)
S.He et al., Cell, 137, 1100 (2009)
S.Karl et al., J. Cell. Mol. Med., 13, 4239 (2009)
S.Moriceau et al., J. Immunol., 182, 7254 (2009)
S.P.Cullen et al., J. Biol. Chem., 284, 5137 (2009)
V.A.Rao et al., Cancer Res., 69, 948 (2009)
V.Janssens et al., Biochem. Biophys. Res. Commun., 386, 676 (2009)
Y.Pan et al., Small, 5, 2067 (2009)
A.M.Mackey et al., Cell Death Differ., 15, 1291 (2008)
C.Bouaziz et al., Toxicology, 254, 19 (2008)
C.Sheridan et al., Mol. Cell, 31, 570 (2008)
D.H.Zhou et al., Hepatobiliary Pancreat. Dis. Int., 7, 201 (2008)
M.Galle et al., J. Cell. Mol. Med., 12, 1767 (2008)
N.Hajji et al., Oncogene, 27, 3134 (2008)
S.Baumann et al., Blood, 111, 2354 (2008)
Y.Okawa et al., Br. J. Haematol., 141, 659 (2008)
A.Vejux et al., Histochem. Cell Biol., 127, 609 (2007)
D.Alvira et al., Neuroscience, 146, 350 (2007)
J.A.Emamaullee et al., Diabetes, 56, 1289 (2007)
J.R.Matthews et al., BMC Cancer, 7, 29 (2007)
K.La Ferla-Bruhl et al., Oncogene, 26, 571 (2007)
K.Meuer et al., Cell Death Differ., 14, 651 (2007)
K.U.Chow et al., Leuk. Lymphoma, 48, 1379 (2007)
L.Bojic et al., FEBS Lett., 581, 5185 (2007)
M.Gomez-Benito et al., Cell Signal., 19, 844 (2007)
M.M.McKay and D.K.Morrison, J. Biol. Chem., 282, 26225 (2007)
R.Abou-Merhi et al., Leukemia, 21, 1792 (2007)
S.Giagkousiklidis et al., Oncogene, 26, 7006 (2007)
Y.Cai et al., Free Radic. Biol. Med., 42, 64 (2007)
A.Dumay et al., Free Radic. Biol. Med., 40, 1377 (2006)
A.G.Rossi et al., Nat. Med., 12, 1056 (2006)
A.Muhlethaler-Mottet et al., BMC Cancer, 6, 214 (2006)
C.Adrain et al., J. Biol. Chem., 281, 8118 (2006)
C.Adrain et al., J. Biol. Chem., 281, 8118 (2006)
C.Scheller et al., J. Cell Biochem., 97, 1350 (2006)
H.G.Mannherz et al., Eur. J. Cell Biol., 85, 785 (2006)
J.Aarbiou et al., Inflamm. Res., 55, 119 (2006)
M.J.van Nimwegen et al., Mol. Pharmacol., 70, 1330 (2006)
N.Buron et al., Invest. Ophthalmol. Vis. Sci., 47, 4221 (2006)
P.Delivani et al., Mol. Cell, 21, 761 (2006)
S.Aulwurm et al., Int. J. Cancer, 118, 1728 (2006)
A.Saumet et al., Blood, 106, 658 (2005)
C.Lorz et al., Kidney Int., 67, 592 (2005)
C.P.Lawrence and S.C.Chow, FEBS Lett., 579, 6465 (2005)
F.Doonan et al., Invest. Ophthalmol. Vis. Sci., 46, 3530 (2005)
J.Hynes et al., J. Immunol. Methods, 306, 193 (2005)
K.Ishitsuka et al., Oncogene, 24, 5888 (2005)
M.Gomez-Benito et al., FEBS Lett., 579, 6217 (2005)
M.Klenk et al., Cell. Microbiol., 7, 1237 (2005)
M.Montolio et al., Cell Transplant., 14, 59 (2005)
M.P.Catalan et al., Kidney Int., 68, 1303 (2005)
N.Kopitar-Jerala et al., FEBS Lett., 579, 2149 (2005)
P.Boya et al., Mol. Cell. Biol., 25, 1025 (2005)
R.A.Gonzalez-Polo et al., Oncogene, 24, 7503 (2005)
S.Kumar et al., Cell Cycle, 4, 1667 (2005)
S.Nolasco et al., FEBS Lett., 579, 3515 (2005)
T.C.O'Riordan et al., Anal. Biochem., 342, 111 (2005)
U.Gregorc et al., Biol. Chem., 386, 705 (2005)
C.J.Auernhammer et al., J. Endocrinol., 180, 479 (2004)
J.Falsig et al., J. Neurochem., 88, 181 (2004)
M.M.Willcocks et al., J. Gen. Virol., 85, 1125 (2004)
M.Napirei et al., Arthritis Rheum., 50, 1873 (2004)
R.S.Akundi et al., J. Neurochem., 91, 623 (2004)
T.Bartke et al., Mol. Cell, 14, 801 (2004)
A.Hueber et al., Invest. Ophthalmol. Vis. Sci., 44, 2851 (2003)
A.Iwata et al., J. Immunol., 170, 3386 (2003)
B.A.Kefas et al., Diabetologia, 46, 205 (2003)
D.Iglesias-Serret et al., Arch. Biochem. Biophys., 417, 141 (2003)
I.Mlinaric-Rascan and B.Turk, FEBS Lett., 553, 51 (2003)
J.Rozman-Pungercar et al., Cell Death Differ., 10, 881 (2003)
K.Aoshiba et al., Am. J. Respir. Cell Mol. Biol., 28, 555 (2003)
K.J.Tronstad et al., Chem. Biol., 10, 609 (2003)
L.Egger et al., Cell Death Differ., 10, 1188 (2003)
L.Peduto Eberl et al., Br. J. Cancer, 88, 788 (2003)
M.Ejercito and J.Wolfe, J. Eukaryot. Microbiol., 50, 427 (2003)
T.Xiao et al., J. Toxicol. Environ. Health A., 66, 469 (2003)
U.Lademann et al., Mol. Cell Biol., 23, 7829 (2003)
D.Meisse et al., FEBS Lett., 526, 38 (2002)
M.C.Plotkowski et al., Am. J. Respir. Cell Mol. Biol., 26, 617 (2002)
M.Shiohara et al., Biochem. Biophys. Res. Commun., 293, 1314 (2002)
S.M.Schrier et al., Biochem. Pharmacol., 63, 1119 (2002)
V.Duverger et al., Int. J. Cancer, 97, 706 (2002)
W.Kugler et al., J. Neurochem., 82, 1160 (2002)
Y.H.Ling et al., Mol. Cancer Ther., 1, 841 (2002)
C.Volbracht et al., Mol. Med., 7, 36 (2001)
G.Dorothee et al., Int. J. Cancer, 91, 772 (2001)
M.Lauricella et al., FEBS Lett., 499, 191 (2001)
N.Olmo et al., Eur. J. Biochem., 268, 2113 (2001)
R.Neviere et al., Am. J. Respir. Crit. Care Med., 163, 218 (2001)
A.K.Soderpalm et al., Invest. Ophthalmol. Vis. Sci., 41, 937 (2000)
E.Jacotot et al., J. Exp. Med., 191, 33 (2000)
L.P.Eberl et al., Int. J. Cancer, 86, 182 (2000)
L.Rossig et al., J. Am. Coll. Cardiol., 36, 2081 (2000)
P.Storz et al., Cell Death Differ., 7, 955 (2000)
S.H.Leech et al., Int. J. Cancer, 86, 570 (2000)
B.B.Wolf et al., J. Biol. Chem., 274, 30651 (1999)
H.Puthalakath et al., Mol. Cell, 3, 287 (1999)
J.Zhu et al., Proc. Natl. Acad. Sci. USA, 96, 14807 (1999)
T.Pillot et al., J. Neurochem., 73, 1626 (1999)
D.J.Granville et al., FEBS Lett., 437, 5 (1998)
I.Marzo et al., FEBS Lett., 427, 198 (1998)
R.Schlapbach and A.Fontana, Biochim. Biophys. Acta, 1359, 147 (1997)

Product citations

J.A.Emamaullee et al., Diabetes, 56, 1289 (2007)
S.Misaghi et al., Cell Death Differ., 13, 163 (2006)
S.Misaghi et al., Chem. Biol., 11, 1677 (2004)
M.Sawada, Nat. Cell Biol., 5, 352 (2003)
M.Garcia-Calvo et al., J. Biol. Chem., 273, 32608 (1998)
R.Iyer and A.Holian, Am. J. Physiol., 273, L760 (1997)
H.Zhu et al., FEBS Lett., 374, 303 (1995)

4026865

Enzyme Substrates Inhibitors
Caspase-1 (ICE)    
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase)    
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