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4026865

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Z-Val-Ala-DL-Asp-fluoromethylketone

4026865

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4026865.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
4026865.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,261.00
CHF 1,172.73 (7%)
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Details

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis.
Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560,
Inhibitor of peptide:N-glycanase (PNGase).
Catalog Number N-1510
Synonyms Z-VAD-FMK
Molecular Formula C₂₁H₂₈FN₃O₇
Relative Molecular Mass 453.47
CAS Registry Number [220644-02-0]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Pan-caspase inhibitor
Areas of Interest Apoptosis & Necrosis
Cancer Research
Links / Documents:
Brochures:

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Product citations

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4026865

Enzyme Substrates Inhibitors
Caspase-1 (ICE)    
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase)    
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