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Details
zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis.
Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560.
Inhibitor of peptide:N-glycanase (PNGase).
Catalog Number
N-1510
Synonyms
Z-VAD-FMK
Molecular Formula
C₂₁H₂₈FN₃O₇
Relative Molecular Mass
453.47
CAS Registry Number
220644-02-0
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Pan-caspase inhibitor
Application
Apoptosis & Necrosis
Cancer Research
Cancer Research
Links / Documents:
Brochures:
Bachem product citations
M.Yamaguchi et al.,
International Journal of Oral-Medical Sciences,
16,
31 (2017)
S.B.Berger et al.,
Cell Death Discov.,
1,
15009 (2015)
X.S.Sun et al.,
J. Cancer Ther.,
2,
418 (2011)
M.S.I.Abaza,
Exp. Ther. Med,
1,
675 (2010)
Product citations
4026865
Enzyme | Substrates | Inhibitors |
---|---|---|
Caspase-1 (ICE) | ||
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase) |