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4026865

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Z-Val-Ala-DL-Asp-fluoromethylketone

4026865

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4026865.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
4026865.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,261.00
CHF 1,172.73 (7%)
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Details

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis.
Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560,
Inhibitor of peptide:N-glycanase (PNGase).
Catalog Number N-1510
Synonyms Z-VAD-FMK
Molecular Formula C₂₁H₂₈FN₃O₇
Relative Molecular Mass 453.47
CAS Registry Number [220644-02-0]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Pan-caspase inhibitor
Areas of Interest Apoptosis & Necrosis
Cancer Research
Links / Documents:
Brochures:

Bachem product citations

M.H.Bashari et al., Breast Cancer Res., 18, 26 (2016)
L.Kinzel et al., Oncotarget, 7, 43199 (2016)
C.Lawlor et al., PLoS One, 11, e0149167 (2016)
M.Schirmer et al., Cell Death Dis., 7, e2052 (2016)
S.B.Berger et al., Cell Death Discov., 1, 15009 (2015)
Z.Baranski et al., Oncotarget, 6, 36113 (2015)
M.F.Brown et al., Cell Death Dis., 6, e1729 (2015)
U.Cersosimo et al., J. Med. Chem., 58, 1691 (2015)
L.Y.Chiu et al., PLoS One, 10, e0125774 (2015)
S.Cristofanon et al., Cell Death Dis., 6, e1724 (2015)
N.Echeverry et al., Cell Death Dis., 6, e1757 (2015)
M.Fares et al., Biochem. Biophys. Res. Commun., 463, 268 (2015)
J.M.Gajer et al., Oncogenesis, 4, e137 (2015)
P.Geserick et al., Cell. Death Dis., 6, e1884 (2015)
C.D.Lucas et al., Am. J. Respir. Crit. Care Med., 191, 626 (2015)
B.B.Manshian et al., Sci. Rep., 5, 13890 (2015)
M.Najjar et al., Cell. Rep., 10, 1850 (2015)
F.A.Abulwerdi et al., J. Med. Chem., 57, 4111 (2014)
R.G.Carroll et al., Cell. Rep., 9, 1538 (2014)
F.De Nicola et al., Cell Death Dis., 5, e1414 (2014)
A.Degterev et al., Methods Enzymol., 545, 1 (2014)
M.Ehrenschwender et al., Cell Death Dis., 5, e1570 (2014)
Y.Estornes et al., Cell Death Dis., 5, e1555 (2014)
E.Hollville et al., Mol. Cell, 55, 451 (2014)
C.J.Kearney et al., FEBS J., 281, 4921 (2014)
W.C.Lin et al., Cell Death Dis., 5, e1109 (2014)
W.C.Lin et al., Cell Death Dis., 5, e1109 (2014)
D.Lissa et al., Proc. Natl. Acad. Sci. USA, 111, 3020 (2014)
K.E.McCabe et al., Cell Death Dis., 5, e1496 (2014)
A.M.Pedersen et al., Int. J. Oncol., 45, 2167 (2014)
G.Perez-Chacon et al., Pharmacol. Res., 89, 46 (2014)
Q.Remijsen et al., Cell Death Dis., 5, e1004 (2014)
H.Song et al., PLoS One, 9, e114457 (2014)
A.Weilbacher et al., Cell Death Dis., 5, e1318 (2014)
S.P.Cullen et al., Mol. Cell, 49, 1034 (2013)
K.Demeyere et al., Vet. Immunol. Immunopathol., 153, 45 (2013)
C.Friesen et al., Eur. J. Cancer, 49, 2542 (2013)
C.Gallerne et al., Biochim. Biophys. Acta, 1833, 1356 (2013)
C.R.McNamara et al., PLoS One, 8, e56576 (2013)
C.A.Patwardhan et al., J. Biol. Chem., 288, 7313 (2013)
E.Preuss et al., J. Biol. Chem., 288, 35287 (2013)
F.Rapino et al., Cell Death Dis., 4, e925 (2013)
C.Seitz et al., Int. J. Cancer, 132, 2682 (2013)
J.Sosna et al., Cell Commun. Signal, 11, 76 (2013)
L.Steinhart et al., Cell Death Dis., 4, e802 (2013)
N.Syed et al., Cell Death Dis., 4, e458 (2013)
L.Vela et al., J. Biol. Chem., 288, 4935 (2013)
A.C.Vion et al., Pulm. Circ., 3, 95 (2013)
R.Weiss et al., Cell Death Dis., 20, 823 (2013)
S.Y.Yang et al., Evid. Based Complement. Alternat. Med., 2013, 630415 (2013)
J.I.Aguilo et al., Chem. Biol. Interact., 198, 18 (2012)
F.Basit et al., J. Biol. Chem., 287, 38767 (2012)
F.Bensassi et al., Toxicol. In Vitro, 26, 915 (2012)
F.Bensassi et al., Food Chem. Toxicol., 50, 1680 (2012)
L.Duprez et al., J. Biol. Chem., 287, 14863 (2012)
M.Jemaa et al., Cell Cycle, 11, 2149 (2012)
M.Jemaa et al., EMBO Mol. Med., 4, 500 (2012)
D.Kogel et al., Neurobiol. Aging, 33, 2200 (2012)
R.Martin-Perez et al., Apoptosis, 17, 349 (2012)
A.Rodriguez-Enfedaque et al., Biochim. Biophys. Acta, 1823, 1343 (2012)
R.W.Rooswinkel et al., Cell Death Dis., 3, e366 (2012)
O.Sharaf el dein et al., Biochem. Pharmacol., 83, 1172 (2012)
T.Sun et al., Front. Mol. Neurosci., 5, 93 (2012)
L.Verschooten et al., PLoS One, 7, e48264 (2012)
Z.Wang et al., Cell, 148, 228 (2012)
X.S.Sun et al., J. Cancer Ther., 2, 418 (2011)
N.Badiola et al., Cell Death Dis., 2, e149 (2011)
J.Balart et al., Radiat Oncol, 6, 6 (2011)
C.Bedia et al., J. Biol. Chem., 286, 28200 (2011)
F.Bensassi et al., Toxicology, 290, 230 (2011)
J.G.Christian et al., PLoS Pathog., 7, e1002283 (2011)
M.Feoktistova et al., Mol. Cell., 43, 449 (2011)
L.Fredriksson et al., Hepatology, 53, 2027 (2011)
B.Laukens et al., Neoplasia, 13, 971 (2011)
R.T.Lima et al., J. Cell. Biochem., 112, 200 (2011)
A.S.Michallet et al., PLoS One, 6, e25820 (2011)
G.Polier et al., Cell Death Dis., 2, e182 (2011)
J.Rudner et al., Biochem. Pharmacol., 81, 32 (2011)
D.Stadel et al., Neoplasia, 13, 1162 (2011)
L.Vela et al., J. Inorg. Biochem., 105, 1306 (2011)
Y.M.Wang et al., Bone, 48, 1336 (2011)
M.S.I.Abaza, Exp. Ther. Med, 1, 675 (2010)
N.Le Floch et al., Biochem. Biophys. Res. Commun., 399, 173 (2010)
J.Rudner et al., Biochem. Pharmacol., 79, 10 (2010)
S.Ussat et al., Scand. J. Immunol., 72, 388 (2010)
R.Alonso et al., Blood, 114, 1563 (2009)
R.Calafell et al., Eur. J. Pharmacol., 610, 128 (2009)
L.Castera et al., J. Cell Mol. Med., 13, 1321 (2009)
S.P.Cullen et al., J. Biol. Chem., 284, 5137 (2009)
D.Fuchs et al., Biochem. Biophys. Res. Commun., 390, 743 (2009)
S.He et al., Cell, 137, 1100 (2009)
V.Janssens et al., Biochem. Biophys. Res. Commun., 386, 676 (2009)
S.Karl et al., J. Cell. Mol. Med., 13, 4239 (2009)
A.U.Luthi et al., Immunity, 31, 84 (2009)
G.D.Maurer et al., Neuro. Oncol., 11, 747 (2009)
S.Moriceau et al., J. Immunol., 182, 7254 (2009)
G.O'Sullivan-Coyne et al., Br. J. Cancer, 101, 1585 (2009)
Y.Pan et al., Small, 5, 2067 (2009)
J.C.Puigvert et al., Mol. Pharmacol., 75, 947 (2009)
V.A.Rao et al., Cancer Res., 69, 948 (2009)
S.Baumann et al., Blood, 111, 2354 (2008)
C.Bouaziz et al., Toxicology, 254, 19 (2008)
M.Galle et al., J. Cell. Mol. Med., 12, 1767 (2008)
N.Hajji et al., Oncogene, 27, 3134 (2008)
A.M.Mackey et al., Cell Death Differ., 15, 1291 (2008)
Y.Okawa et al., Br. J. Haematol., 141, 659 (2008)
C.Sheridan et al., Mol. Cell, 31, 570 (2008)
R.Abou-Merhi et al., Leukemia, 21, 1792 (2007)
D.Alvira et al., Neuroscience, 146, 350 (2007)
L.Bojic et al., FEBS Lett., 581, 5185 (2007)
Y.Cai et al., Free Radic. Biol. Med., 42, 64 (2007)
K.U.Chow et al., Leuk. Lymphoma, 48, 1379 (2007)
J.A.Emamaullee et al., Diabetes, 56, 1289 (2007)
S.Giagkousiklidis et al., Oncogene, 26, 7006 (2007)
M.Gomez-Benito et al., Cell Signal., 19, 844 (2007)
K.La Ferla-Bruhl et al., Oncogene, 26, 571 (2007)
M.M.McKay and D.K.Morrison, J. Biol. Chem., 282, 26225 (2007)
K.Meuer et al., Cell Death Differ., 14, 651 (2007)
J.Aarbiou et al., Inflamm. Res., 55, 119 (2006)
C.Adrain et al., J. Biol. Chem., 281, 8118 (2006)
C.Adrain et al., J. Biol. Chem., 281, 8118 (2006)
S.Aulwurm et al., Int. J. Cancer, 118, 1728 (2006)
N.Buron et al., Invest. Ophthalmol. Vis. Sci., 47, 4221 (2006)
P.Delivani et al., Mol. Cell, 21, 761 (2006)
A.Dumay et al., Free Radic. Biol. Med., 40, 1377 (2006)
H.G.Mannherz et al., Eur. J. Cell Biol., 85, 785 (2006)
A.Muhlethaler-Mottet et al., BMC Cancer, 6, 214 (2006)
C.Scheller et al., J. Cell Biochem., 97, 1350 (2006)
P.Boya et al., Mol. Cell. Biol., 25, 1025 (2005)
M.P.Catalan et al., Kidney Int., 68, 1303 (2005)
M.Gomez-Benito et al., FEBS Lett., 579, 6217 (2005)
R.A.Gonzalez-Polo et al., Oncogene, 24, 7503 (2005)
U.Gregorc et al., Biol. Chem., 386, 705 (2005)
J.Hynes et al., J. Immunol. Methods, 306, 193 (2005)
K.Ishitsuka et al., Oncogene, 24, 5888 (2005)
M.Klenk et al., Cell. Microbiol., 7, 1237 (2005)
N.Kopitar-Jerala et al., FEBS Lett., 579, 2149 (2005)
C.P.Lawrence and S.C.Chow, FEBS Lett., 579, 6465 (2005)
M.Montolio et al., Cell Transplant., 14, 59 (2005)
S.Nolasco et al., FEBS Lett., 579, 3515 (2005)
T.C.O'Riordan et al., Anal. Biochem., 342, 111 (2005)
A.Saumet et al., Blood, 106, 658 (2005)
R.S.Akundi et al., J. Neurochem., 91, 623 (2004)
C.J.Auernhammer et al., J. Endocrinol., 180, 479 (2004)
T.Bartke et al., Mol. Cell, 14, 801 (2004)
J.Falsig et al., J. Neurochem., 88, 181 (2004)
K.Aoshiba et al., Am. J. Respir. Cell Mol. Biol., 28, 555 (2003)
L.Egger et al., Cell Death Differ., 10, 1188 (2003)
M.Ejercito and J.Wolfe, J. Eukaryot. Microbiol., 50, 427 (2003)
D.Iglesias-Serret et al., Arch. Biochem. Biophys., 417, 141 (2003)
A.Iwata et al., J. Immunol., 170, 3386 (2003)
B.A.Kefas et al., Diabetologia, 46, 205 (2003)
I.Mlinaric-Rascan and B.Turk, FEBS Lett., 553, 51 (2003)
L.Peduto Eberl et al., Br. J. Cancer, 88, 788 (2003)
J.Rozman-Pungercar et al., Cell Death Differ., 10, 881 (2003)
K.J.Tronstad et al., Chem. Biol., 10, 609 (2003)
V.Duverger et al., Int. J. Cancer, 97, 706 (2002)
W.Kugler et al., J. Neurochem., 82, 1160 (2002)
D.Meisse et al., FEBS Lett., 526, 38 (2002)
M.C.Plotkowski et al., Am. J. Respir. Cell Mol. Biol., 26, 617 (2002)
S.M.Schrier et al., Biochem. Pharmacol., 63, 1119 (2002)
M.Shiohara et al., Biochem. Biophys. Res. Commun., 293, 1314 (2002)
G.Dorothee et al., Int. J. Cancer, 91, 772 (2001)
M.Lauricella et al., FEBS Lett., 499, 191 (2001)
R.Neviere et al., Am. J. Respir. Crit. Care Med., 163, 218 (2001)
N.Olmo et al., Eur. J. Biochem., 268, 2113 (2001)
C.Volbracht et al., Mol. Med., 7, 36 (2001)
L.P.Eberl et al., Int. J. Cancer, 86, 182 (2000)
E.Jacotot et al., J. Exp. Med., 191, 33 (2000)
S.H.Leech et al., Int. J. Cancer, 86, 570 (2000)
L.Rossig et al., J. Am. Coll. Cardiol., 36, 2081 (2000)
T.Pillot et al., J. Neurochem., 73, 1626 (1999)
H.Puthalakath et al., Mol. Cell, 3, 287 (1999)
B.B.Wolf et al., J. Biol. Chem., 274, 30651 (1999)
J.Zhu et al., Proc. Natl. Acad. Sci. USA, 96, 14807 (1999)
D.J.Granville et al., FEBS Lett., 437, 5 (1998)
I.Marzo et al., FEBS Lett., 427, 198 (1998)
R.Schlapbach and A.Fontana, Biochim. Biophys. Acta, 1359, 147 (1997)

Product citations

J.A.Emamaullee et al., Diabetes, 56, 1289 (2007)
S.Misaghi et al., Cell Death Differ., 13, 163 (2006)
S.Misaghi et al., Chem. Biol., 11, 1677 (2004)
M.Sawada, Nat. Cell Biol., 5, 352 (2003)
M.Garcia-Calvo et al., J. Biol. Chem., 273, 32608 (1998)
R.Iyer and A.Holian, Am. J. Physiol., 273, L760 (1997)
H.Zhu et al., FEBS Lett., 374, 303 (1995)

4026865

Enzyme Substrates Inhibitors
Caspase-1 (ICE)    
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase)    
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