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Details
HCKFWW, potent inhibitor of the HIV-encoded integrase (IN), the enzyme responsible for the integration of HIV DNA into the human genome. HCKFWW inhibits IN-mediated 3'processing and integration with an IC₅₀ of 2 µM. The peptide is also active on IN proteins from other retroviruses such as HIV-2, feline immunodeficiency virus and Moloney murine leukemia virus. It was also found to inhibit the disintegration reaction, suggesting that this hexapeptide acts at or near the catalytic site of IN.
Catalog Number
H-3524
One Letter Code
HCKFWW
Molecular Formula
C₄₆H₅₅N₁₁O₇S
Relative Molecular Mass
906.08
CAS Registry Number
172546-75-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
HIV integrase inhibitor
Application
Infectious Disease
Virology
Virology
Links / Documents:
Brochures:
Bachem product citations
Product citations
4026848
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| HIV Integrase |
