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Availability: In stock

Fmoc-Tyr(malonyl-di-OtBu)-OH

4026574

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4026574.0100 100 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 430.00
CHF 399.90 (7%)
4026574.0250 250 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 851.00
CHF 791.43 (7%)
4026574.1000 1 g Ships within 3-5 business days  
CHF 2,543.00
CHF 2,364.99 (7%)
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Details

The phosphotyrosine-mimicking amino acid Fmoc-Tyr(malonyl-di-OtBu)-OH can be used as a building block for the synthesis of cell-permeable protein tyrosine phosphatase (PTP) inhibitors. The effect of a malonyl-tyrosine containing peptide on PTP 1B catalyzed insulin receptor dephosphorylation has been examined and it was shown that this peptide inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide.
Catalog Number B-2825
Molecular Formula C₃₅H₃₉NO₉
Relative Molecular Mass 617.70
CAS Registry Number [168135-77-1]
Storage Conditions -20 ± 5 °C
Keywords Phosphotyrosine mimic

Bachem product citations

S.U.Kang and T.R.Burke Jr., Tetrahedron Lett., 45, 8611 (2004)