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Availability: In stock

Grb2 SH2 Domain Ligand


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4026417.0001 1 mg Ships within 3-5 business days  
CHF 357.00
CHF 332.01 (7%)
4026417.0005 5 mg Ships within 3-5 business days  
CHF 1,429.00
CHF 1,328.97 (7%)


pYVNV corresponds to residues 317 to 320 of the oncogenic protein Shc. Similar phosphotyrosine motifs are also found in receptor tyrosine kinases and substrates of them. This peptide binds with high affinity (18 nM) to the SH2 domain of the growth factor bound-2 protein (Grb2). It is a useful inhibitor of the interaction of Grb2 with Shc, or with other Grb-2-binding proteins involved in the cell signaling cascade.
Catalog Number H-2708
Molecular Formula C₂₃H₃₆N₅O₁₀P
Relative Molecular Mass 573.54
CAS Registry Number 168423-05-0
Source Synthetic
Storage Conditions -20 ± 5 °C