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Details
The peptide PSTHVLITHTI corresponds to residues 70-80 of human TNF-α substituted with Ile at position 76 and exhibits many of the biological activities found for TNF-α. (Ile⁷⁶)-TNF-α (70-80) has been shown to enhance human polymorphonuclear-mediated killing of Plasmodium falciparum in vitro and to reduce Plasmodium chabaudi parasitemia in mice. However, in vivo toxicity studies showed that (Ile⁷⁶)-TNF-α (70-80) does not possess the typical toxic effects of TNF.
Catalog Number
H-2698
One Letter Code
PSTHVLITHTI
Molecular Formula
C₅₅H₉₁N₁₅O₁₆
Relative Molecular Mass
1218.42
CAS Registry Number
[163045-82-7]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Apoptosis & Necrosis
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