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Details
The 35 amino acid peptide NAC (α-synuclein (61-95)) has originally been isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. The sequence corresponds to a fragment of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
Catalog Number
H-2598
APC Number
62-5-25
One Letter Code
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV
Synonyms
NAC, Non-Aβ Component of Alzheimer's Disease Amyloid, Non-β-Amyloid Component of Alzheimer's Disease (NAC)
Molecular Formula
C₁₄₁H₂₃₅N₃₉O₄₉
Relative Molecular Mass
3260.65
CAS Registry Number
154040-19-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Parkinson's Disease
Parkinson's Disease
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