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Details
L-NIL inhibited mouse inducible nitric oxide synthase with an IC₅₀ of 3.3 µM compared to an IC₅₀ of 92 µM obtained for rat brain constitutive NOS. The lysine-derived inhibitor may be useful as a selective and potent inhibitor of inducible NOS for determining the role of this enzyme in disease models (e.g. chronic inflammation and autoimmune diseases). Bryk et al. studied the suicidal disactivation of neuronal NOS by L-NIL.
Catalog Number
F-3325
Synonyms
H-Lys(1-iminoethyl)-OH, N-(5-Amino-5-carboxypentyl)-acetamidine, L-NIL
Molecular Formula
C₈H₁₇N₃O₂
Relative Molecular Mass
187.24
CAS Registry Number
53774-63-3
Storage Conditions
-20 ± 5 °C
Keywords
NOS inhibitor
Application
Inflammation Research
Nitric Oxide Research
Nitric Oxide Research
Links / Documents:
Bachem product citations
4026182
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Nitric Oxide Synthase |
