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Details
Sieber amide resin has been developed for the Fmoc-SPPS of fully t-butyl protected peptide amides. Cleavage can be achieved with 1% TFA in methylene chloride. Scavengers may be required. As N-methylation increases the acid-lability of the peptide bond, Malakoutikhah et al. employed Sieber resin for obtaining short peptide amides containing multiple MePhe residues.
Catalog Number
D-2040
Synonyms
Sieber Amide Resin
Substitution
0.4-0.7 mmol/g
Storage Conditions
+5 ± 3 °C
Links / Documents:
Brochures:
Bachem product citations
Product citations
S.A.Kates et al.,
Peptides 1994, Proceedings of the 23rd European Peptide Symposium, Braga/ Portugal, p. 262, H.L.S.Maia, ed., Escom, Leiden,
(1995)
P.Sieber,
Tetrahedron Lett.,
28,
2107 (1987)
