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Details
In vitro, BQ-788 potently and competitively inhibited ¹²⁵I-labeled ET-1 binding to ET-B receptors on human Girardi heart cells (IC₅₀= 1.2 nM). However, BQ-788 only poorly inhibited ET-1 binding to ET-A receptors on human neuroblastoma cell line SK-N-MC cells (IC₅₀= 1300 nM). Thus the ET-B receptor antagonist BQ788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.
Catalog Number
H-2492
Molecular Formula
C₃₄H₅₁N₅O₇
Relative Molecular Mass
641.81
CAS Registry Number
173326-37-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Endothelin antagonist
Application
Cardiovascular System & Diseases
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