Shopping Cart - CHF 0.00

You have no items in your shopping cart.

  • Home  » 
  • 4026108
Return to Previous Page
4026108

Availability: In stock

BQ-788
N-cis-2,6-Dimethylpiperidinocarbonyl-β-tBu-Ala-D-Trp(1-methoxycarbonyl)-D-Nle-OH

4026108

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4026108.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 273.00
CHF 253.89 (7%)
4026108.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,092.00
CHF 1,015.56 (7%)

Details

In vitro, BQ-788 potently and competitively inhibited ¹²⁵I-labeled ET-1 binding to ET-B receptors on human Girardi heart cells (IC₅₀= 1.2 nM). However, BQ-788 only poorly inhibited ET-1 binding to ET-A receptors on human neuroblastoma cell line SK-N-MC cells (IC₅₀= 1300 nM). Thus the ET-B receptor antagonist BQ788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.
Catalog Number H-2492
Molecular Formula C₃₄H₅₁N₅O₇
Relative Molecular Mass 641.81
CAS Registry Number 173326-37-9
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Endothelin antagonist
Application Cardiovascular System & Diseases
Links / Documents:

Bachem product citations

K.Yuan et al., Peptides, 82, 12 (2016)
T.M.Leurgans et al., Br. J. Pharmacol., 173, 1653 (2016)
F.Amraoui et al., PLoS One, 9, e91897 (2014)
A.S.Ahmedat et al., Br. J. Pharmacol., 168, 471 (2013)
A.S.Ahmedat et al., Br. J. Pharmacol., 168, 471 (2013)
I.Drygiannakis et al., J. Crohns Colitis, 7, 286 (2013)
J.P.Knowles et al., Int. J. Cancer, 130, 1264 (2012)
J.P.Knowles et al., Int. J. Cancer, 130, 1264 (2012)
M.J.Meens et al., PLoS One, 5, e10917 (2010)
M.Paolillo et al., Pharmacol. Res., 61, 306 (2010)
P.K.Patibandla et al., J. Cell. Physiol., 221, 195 (2009)
A.Palladini et al., Eur. J. Cancer, 42, 680 (2006)
C.E.Waters et al., Arthritis Rheum., 54, 649 (2006)
C.R.Mangahas et al., J. Invest. Dermatol., 125, 307 (2005)
M.Fang et al., J. Physiol., 549, 903 (2003)
S.Blouquit et al., Am. J. Respir. Cell. Mol. Biol., 29, 245 (2003)
G.Prasanna et al., Invest. Ophthalmol. Vis. Sci., 43, 2704 (2002)
S.Jamal and R.J.Schneider, J. Clin. Invest., 110, 443 (2002)
E.Naline et al., Br. J. Pharmacol., 126, 529 (1999)

Product citations

M.Okada and M.Nishikibe, Cardiovasc. Drug Rev., 20, 53 (2002)
R.J.Johnson et al., J. Pharmacol. Exp. Ther., 289, 762 (1999)
K.Ishikawa et al., Proc. Natl. Acad. Sci. USA, 91, 4892 (1994)
Related products