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Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland.
According to a study of Nguyen et al. Pyr-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.
Catalog Number
H-2464
APC Number
79-2-25
One Letter Code
pEEP-NH₂
Synonyms
FPP, Fertilization-Promoting Peptide, pE-E-P-NH2
Molecular Formula
C₁₅H₂₂N₄O₆
Relative Molecular Mass
354.36
CAS Registry Number
85541-78-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Di- and Tripeptides
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