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Details
Z-FK-ck is a very effective in vivo cathepsin B inhibitor in rats. It inhibited rat liver cathepsin B activity ex vivo with ED₅₀ = 5 mg/kg intraperitoneally and 18 mg/kg orally at 4-5 h postdose, and 2.4 mg/kg subcutaneously at 24 h postdose. It also inhibited rat cathepsin B activity in heart and skeletal muscle with ED₅₀ = 0.1 and 1.0 mg/kg subcutaneously at 20 h postdose. Z-FK-ck is an inhibitor of gingipain K.
Catalog Number
N-1400
Synonyms
Z-FK-ck
Molecular Formula
C₃₄H₄₁N₃O₆
Relative Molecular Mass
587.72
CAS Registry Number
[118253-05-7] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Cathepsin B inhibitor
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Bachem product citations
K.N.Hosn et al.,
Clinical and Experimental Dental Research,
1,
18 (2015)
4025803
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Cathepsin B | ||
| Gingipain K |
