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Details
This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²⁵I-labeled APP to heparin (IC₅₀= 10⁻⁷M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.
Catalog Number
H-2232
APC Number
62-1-15
One Letter Code
Ac-NWCKRGRKQCKTHPH-NH₂
Synonyms
β-Amyloid / A4 Protein Precursor (APP) (96-110), analog, Ac-APP₇₇₀ (96-110) (cyclized)
Molecular Formula
C₈₁H₁₂₈N₃₂O₁₉S₂
Relative Molecular Mass
1918.24
CAS Registry Number
289634-54-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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