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Details
Efficient fluorogenic substrate for two matrix metalloproteinases: interstitial collagenase (MMP-1) and gelatinase (MMP-9). Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-amide has favorable solubility characteristics. Both enzymes cleave this substrate between Gly and Cys(Me) (Smc), liberating a cleavage product with a fluorescence signal suitable for inhibitor screening and determining Ki values. The major advantage of this FRET substrate is its adaptability to filters commonly available on commercial plate readers (excitation at 365 nm and emission at 450 nm).
Catalog Number
M-2055
APC Number
81-7-90
Synonyms
MMP-1/MMP-9 Substrate, Fluorogenic
Molecular Formula
C₄₉H₆₈N₁₄O₁₂S
Relative Molecular Mass
1077.23
CAS Registry Number
150956-92-6
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
Inflammation Research
Inflammation Research
Links / Documents:
Bachem product citations
4025472
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Gelatinase B | ||
| Interstitial Collagenase | ||
| Matrix Metalloproteinase-1 (MMP-1) | ||
| Matrix Metalloproteinase-9 (MMP-9) |
