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Details
Glu-derivative for the selective modification of the γ-carboxyl group. The OPp group can be removed selectively in the presence of Boc/OtBu with 1% TFA/DCM. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. Tofteng et al. generated a backbone pyroglutamyl imide moiety from C-terminal Glu after selective on-resin OPp removal.
Catalog Number
B-2500
Synonyms
Fmoc-Glu(O-2-PhiPr)-OH, Fmoc-Glu(OPp)-OH
Molecular Formula
C₂₉H₂₉NO₆
Relative Molecular Mass
487.55
CAS Registry Number
200616-39-3
Storage Conditions
-20 ± 5 °C
Links / Documents:
Bachem product citations
Product citations
F.Dick et al.,
Peptides 1996, Proceedings of the 24th European Peptide Symposium, Edinburgh, Scotland, p. 339, R.Ramage and R.Epton, eds., Mayflower Scientific Ltd., England,
(1998)