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Details
In vitro, L-732'138 displaced [¹²⁵I]substance P (SP) from the cloned NK-1 receptor expressed in Chinese hamster ovary cells with IC₅₀ = 1.6 nM. It inhibited competitively SP-induced inositol phosphate accumulation in these cells with Kb = 25 nM. Affinity for NK-2 and NK-3 receptors was weaker than 5 μM.
Catalog Number
E-3135
Synonyms
L-732138
Molecular Formula
C₂₂H₁₈F₆N₂O₃
Relative Molecular Mass
472.39
CAS Registry Number
148451-96-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
NK1 antagonist
Application
Cancer Research
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