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Details
B581, Cys-psi(CH₂NH)-Val- psi[CH₂NH]-Phe-Met is a farnesyltransferase (FTase) inhibitor of special stability and membrane permeability. Due to its high selectivity, B581 is more than 30-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase). Inhibitors of the farnesyltransferase are potential candidates for the development of anticancer drugs.
Catalog Number
N-1390
APC Number
91-1-29
Synonyms
B581, N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-Phe-Met-OH, Farnesyltransferase inhibitor
Molecular Formula
C₂₂H₃₈N₄O₃S₂
Relative Molecular Mass
470.70
CAS Registry Number
149759-96-6
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
Links / Documents:
Brochures:
4025336
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Farnesyl-Diphosphate Farnesyltransferase |
