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Details
Exendin-4 (exenatide), originally isolated from Heloderma suspectum venom, differs from exendin-3 by only 2 N-terminal amino acid substitutions. This polypeptide causes an increase in acinar cAMP without stimulating amylase release. Exendin-4 and glucagon-like peptide 1 (7-36) amide bind with similar affinity to the glucagon-like peptide 1 receptor. Moreover, exendin-4 is also considered for clinical use in the treatment of type 2 diabetes.
Catalog Number
H-8730
APC Number
46-3-12
One Letter Code
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH₂
Synonyms
Exendin-4
Molecular Formula
C₁₈₄H₂₈₂N₅₀O₆₀S
Relative Molecular Mass
4186.63
CAS Registry Number
141758-74-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
GLP-1 agonist
Application
Diabetes
Parkinson's Disease
Veterinary Medicine
Parkinson's Disease
Veterinary Medicine
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