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4019226

Availability: In stock

Dolastatin 15
(5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

4019226

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4019226.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 158.00
CHF 146.94 (7%)
4019226.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 473.00
CHF 439.89 (7%)
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Details

Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED₅₀ value of 2.4 ng/mL.
Catalog Number H-8630
Molecular Formula C₄₅H₆₈N₆O₉
Relative Molecular Mass 837.07
CAS Registry Number [123884-00-4]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Apoptosis & Necrosis
Cancer Research
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Product citations

M.Sato et al., Int. J. Oncol., 30, 1453 (2007)
J.Poncet, Curr. Pharm. Des., 5, 139 (1999)
M.A.Ali et al., Anticancer Res., 18, 1021 (1998)
Z.-B.Hu et al., Leukemia Res., 17, 333 (1993)
N.Patino et al., Tetrahedron, 48, 4115 (1992)