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Details
Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED₅₀ value of 2.4 ng/mL.
Catalog Number
H-8630
Molecular Formula
C₄₅H₆₈N₆O₉
Relative Molecular Mass
837.07
CAS Registry Number
123884-00-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Apoptosis & Necrosis
Cancer Research
Cancer Research
Links / Documents:
Product citations
N.Patino et al.,
Tetrahedron,
48,
4115 (1992)