Return to Previous Page
Details
The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 4·10³ M⁻¹s⁻¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Boc-RVRR-AMC is also cleaved by proprotein convertase 4.
Stock solutions of Boc-RVRR-AMC are best prepared in DMSO.
Catalog Number
I-1645
APC Number
81-7-40
One Letter Code
Boc-RVRR-AMC
Molecular Formula
C₃₈H₆₂N₁₄O₈
Relative Molecular Mass
843.01
CAS Registry Number
136132-77-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Furin substrate
Links / Documents:
Bachem product citations
4018735
Enzyme | Substrates | Inhibitors |
---|---|---|
Furin | ||
Proprotein Convertase 4 |