Shopping Cart - CHF 0.00

You have no items in your shopping cart.

  • Home  » 
  • 4018149
Return to Previous Page
4018149

Availability: In stock


Pyr-Arg-Thr-Lys-Arg-AMC trifluoroacetate salt

4018149

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4018149.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 105.00
CHF 97.65 (7%)
4018149.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 420.00
CHF 390.60 (7%)

Details

The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 2·10⁴ M-¹s-¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Also cleaved by proprotein convertase 4. Pyr-RTKR-AMC is an excellent substrate for flavivirin.
Catalog Number I-1650
Molecular Formula C₃₇H₅₇N₁₃O₉
Relative Molecular Mass 827.94
CAS Registry Number 155575-02-3
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Furin substrate
Links / Documents:

Bachem product citations

I.Maluch et al., J. Med. Chem., 60, 2732 (2017)
S.Heng et al., J. Cancer, 7, 1812 (2016)
A.Kwiatkowska et al., J. Med. Chem., 57, 98 (2014)
F.Couture et al., Neoplasia, 16, 634 (2014)
N.Vodovar et al., Eur. Heart J., 35, 3434 (2014)
J.Zhu et al., Biochim. Biophys. Acta, 1833, 1924 (2013)
G.L.Becker et al., J. Biol. Chem., 287, 21992 (2012)
H.Singh et al., Biochem. Biophys. Res. Commun., 419, 809 (2012)
M.Aljofan et al., Contraception, 85, 602 (2012)
G.Nie and A.N.Stephens, Methods Mol. Biol., 768, 325 (2011)
M.Kuester et al., Biol. Chem., 392, 973 (2011)
J.Joy et al., FEBS Lett., 584, 3149 (2010)
A.Basak et al., Protein Expr. Purif., 60, 117 (2008)
N.Komatsu et al., J. Invest. Dermatol., 128, 1148 (2008)
M.J.Richer et al., J. Biol. Chem., 279, 10222 (2004)
R.Blakytny et al., J. Cell Physiol., 199, 67 (2004)
Z.X.Liu et al., FEBS Lett., 556, 116 (2004)
M.Fugere et al., J. Biol. Chem., 277, 7648 (2002)
T.Komiyama and R.S.Fuller, Biochemistry, 39, 15156 (2000)

Product citations

A.Basak et al., Protein Expr. Purif., 60, 117 (2008)
S.A.Shiryaev et al., J. Virol., 81, 4501 (2007)
N.S.Lamango et al., Arch. Biochem. Biophys., 330, 238 (1996)
K.Hatsuzawa et al., J. Biol. Chem., 267, 16094 (1992)

4018149

Enzyme Substrates Inhibitors
Furin    
Flavivirin    
Proprotein Convertase 4