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Details
The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 2·10⁴ M-¹s-¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Also cleaved by proprotein convertase 4.
Pyr-RTKR-AMC is an excellent substrate for flavivirin.
Catalog Number
I-1650
Molecular Formula
C₃₇H₅₇N₁₃O₉
Relative Molecular Mass
827.94
CAS Registry Number
155575-02-3
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Furin substrate
Links / Documents:
Bachem product citations
4018149
Enzyme | Substrates | Inhibitors |
---|---|---|
Furin | ||
Flavivirin | ||
Proprotein Convertase 4 |