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Details
Leu-Valorphin-Arg, LVVYPWTQR, corresponds to the sequence (32-40) of the β-,δ-,γ-, and ε-chains of human hemoglobin. It shows binding affinity for µ- and sigma-opioid receptors and has opioid activity in the GPI bioassay. LVV-Hemorphin-6 is found in large amounts in the pituitary and seems to be present in the circulation to a much lesser degree. In view of its high stability towards the membrane-bound lung enzymes and its strong inhibitory action on ACE activity, LVV-hemorphin-6 appears to be the most potent of the hemorphin-related peptides assayed.
Catalog Number
H-8880
One Letter Code
LVVYPWTQR
Synonyms
LVV-Hemorphin-6 (human), Spinorphin-Gln-Arg
Molecular Formula
C₅₆H₈₄N₁₄O₁₃
Relative Molecular Mass
1161.37
CAS Registry Number
[135861-77-7]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Opioid Research
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Bachem product citations
4018140
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Peptidyl-Dipeptidase A | ||
| Angiotensin I-Converting Enzyme (ACE) |
