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Details
Substrate for S-adenosyl-methionine (SAM)-dependent methyltransferases, which methylate the C-terminal S-farnesyl-cysteine residue of several guanine nucleotidebinding proteins (G proteins) which participate in signal transduction. These include the single subunit "small" G proteins such as the p21 ras-related proteins and the heterotrimeric G proteins such as retinal transducin. Thus, a rapid assay for studying this carboxyl methyltransferase activity has been developed. Interestingly, AFC was also shown to inhibit the methylation of the transducin γ-subunit and of Ras-related proteins.
Catalog Number
M-1935
Synonyms
AFC
Molecular Formula
C₂₀H₃₃NO₃S
Relative Molecular Mass
367.55
CAS Registry Number
135304-07-3
Storage Conditions
-20 ± 5 °C
Keywords
Substrate for S-adenosylmethionine-dependent methyltransferase
Links / Documents:
Product citations
C.Volker et al.,
Methods,
1,
283 (1990)
4018082
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Protein-S-Isoprenylcysteine O-Methyltransferase |
