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4015928

Availability: In stock

Acetyl-Pepstatin
Ac-Val-Val-Sta-Ala-Sta-OH

4015928

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4015928.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 126.00
CHF 117.18 (7%)
4015928.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 504.00
CHF 468.72 (7%)

Details

Acetyl-pepstatin is reported to be an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and of HIV-2 proteinase (Ki = 5 nM at pH 4.7). Ac-Val-Val-Sta-Ala-Sta also inhibits the P. falciparum aspartyl protease plasmepsin II, IC₅₀ 0.6 nM.
Catalog Number N-1250
APC Number 84-0-01
Molecular Formula C₃₁H₅₇N₅O₉
Relative Molecular Mass 643.82
CAS Registry Number 28575-34-0
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Infectious Disease
Links / Documents:

Bachem product citations

P.Naicker et al., FEBS J., 281, 5395 (2014)
C.K.Jana et al., Angew. Chem. Int. Ed. Engl., 50, 8407 (2011)
J.Lee et al., Planta. Med., 75, 268 (2009)
P.N.Fonteh et al., J. Inorg. Biochem., 103, 190 (2009)
A.Velazquez-Campoy and E.Freire, Nat. Protoc., 1, 186 (2006)
J.Yanchunas, Jr. et al., Antimicrob. Agents Chemother., 49, 3825 (2005)
H.Ohtaka et al., Biochemistry, 42, 13659 (2003)
H.Ohtaka et al., Protein Sci., 11, 1908 (2002)

Product citations

J.Hill et al., FEBS J., 352, 155 (1994)
A.D.Richards et al., FEBS Lett., 247, 113 (1989)
A.D.Richards et al., FEBS Lett., 253, 214 (1989)

4015928

Enzyme Substrates Inhibitors
Cathepsin D    
Chymosin    
Pepsin A    
Retropepsin    
Plasmepsin II    
HIV-2 Protease