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Details
The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases.
KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.
Catalog Number
H-1382
APC Number
74-1-26
One Letter Code
KTKCKFLKKC
Synonyms
K-T-K-C-K-F-L-K-K-C
Molecular Formula
C₅₅H₉₇N₁₅O₁₂S₂
Relative Molecular Mass
1224.60
CAS Registry Number
147396-10-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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