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4014447

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Amyloid β-Protein (1-42)
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

4014447

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4014447.0100 0.1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 102.00
CHF 94.86 (7%)
4014447.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 337.00
CHF 313.41 (7%)
4014447.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 505.00
CHF 469.65 (7%)
4014447.5000 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,923.00
CHF 1,788.39 (7%)
4014447.0010 10 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 3,269.00
CHF 3,040.17 (7%)
4014447.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 7,832.00
CHF 7,283.76 (7%)

Details

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.
Catalog Number H-1368
One Letter Code DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Synonyms Aβ42, β-Amyloid (1-42)
Molecular Formula C₂₀₃H₃₁₁N₅₅O₆₀S
Relative Molecular Mass 4514.10
CAS Registry Number 107761-42-2
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease
Antimicrobial & Antiviral Peptides
Links / Documents:
Brochures:

Bachem product citations

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