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4014447

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Amyloid β-Protein (1-42)
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

4014447

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4014447.0100 0.1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 102.00
CHF 94.86 (7%)
4014447.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 337.00
CHF 313.41 (7%)
4014447.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 505.00
CHF 469.65 (7%)
4014447.5000 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,923.00
CHF 1,788.39 (7%)
4014447.0010 10 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 3,269.00
CHF 3,040.17 (7%)
4014447.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 7,832.00
CHF 7,283.76 (7%)

Details

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of this peptide corresponds to the sequence of human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.
Catalog Number H-1368
One Letter Code DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Synonyms β-Amyloid (1-42), Aβ42
Molecular Formula C₂₀₃H₃₁₁N₅₅O₆₀S
Relative Molecular Mass 4514.10
CAS Registry Number 107761-42-2
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Alzheimer's Disease
Antimicrobial & Antiviral Peptides
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Brochures:

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