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Availability: In stock

Hydroxymethyl resin (200-400 mesh, 0.9-1.4 mmol/g)


Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4014323.0025 25 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 220.00
CHF 204.60 (7%)
4014323.0100 100 g Ships within 3-5 business days  
CHF 662.00
CHF 615.66 (7%)
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This resin is ideal for the solid phase immobilization of carboxylic acids. During the attachment of diacids less cross-linking is observed in comparison to Merrifield resin. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the attachment of amines. Furthermore, this resin can be converted into an activated carbonate by using N-methyl morpholine and p-nitrophenyl chloroformate, which has been employed in the synthesis of unsymmetrical diamines and in the solid phase synthesis of hydantoins. Release of carboxylic acids from this resin can be effected by treatment with HF or trifluoromethanesulfonic acid or by hydrogenolysis, scavengers may be required. Alcohols can be liberated by reduction with diisobutylaluminium hydride or LiBH₄, while methyl esters can be produced by transesterfication with MeONa or Ti(OEt)₄/C₂H₅CO₂Me.
Catalog Number D-1160
Synonyms HOCH₂-Ph-polymer
Substitution 0.9-1.4 mmol/g
CAS Registry Number [66072-40-0]
Storage Conditions +5 ± 3 °C

Product citations

D.R.Barn et al., Tetrahedron Lett., 37, 3213 (1996)
B.A.Dressman et al., Tetrahedron Lett., 37, 937 (1996)
M.J.Kurth et al., J. Org. Chem., 59, 5862 (1994)