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N-[(1H-Benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate N-oxide


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4013268.0025 25 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 84.00
CHF 78.12 (7%)


TBTU is successfully used as coupling reagent in solid phase peptide synthesis. It acts as an excellent activating reagent causing low racemization during condensation of peptide segments. A study of the structure of TBTU in solid state as well as in solution by Abdelmoty et al. showed that the compound is a guanidinium N-oxide and not an uronium salt.
Catalog Number Q-1665
Synonyms O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-tetrafluoroborate
Molecular Formula C₁₁H₁₆BF₄N₅O
Relative Molecular Mass 321.09
CAS Registry Number 125700-67-6
EINECS Number 423-040-4
Storage Conditions +5 ± 3 °C

Product citations

I.Abdelmoty et al., Lett. Pept. Sci., 1, 57 (1994)
R.Knorr et al., Peptides 1988, Proceedings of the 20th European Peptide Symposium, Tuebingen, p. 37, G.Jung and E.Bayer, eds., Gruyter, Berlin, (1989)
R.Knorr et al., Tetrahedron Lett., 30, 1927 (1989)
P.Henklein et al., Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 5th International Symposium, London, p. 309, R.Epton, ed., Mayflower Scientific (1998),