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4012712

Availability: In stock

SASRIN™ resin (200-400 mesh, 0.80-1.20 mmol/g)
2-Methoxy-4-alkoxybenzyl alcohol resin

4012712

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4012712.0001 1 g Ships within 3-5 business days  
CHF 115.00
CHF 106.95 (7%)
4012712.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 442.00
CHF 411.06 (7%)
4012712.0025 25 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,765.00
CHF 1,641.45 (7%)

Details

SASRIN™ (=Super Acid Sensitive ResIN) was developed in our own laboratories especially for Fmoc solid phase synthesis (EP 0 292 729, US 4,831,084 and US 4,914,151). Its high acid lability enables the cleavage and isolation of the protected peptide fragment. Beside SPPS SASRIN™ has been used in several organic reactions like the synthesis of 4-aryl substituted β-lactams employing Suzuki and Heck couplings, the synthesis of β-sultams, quinazoline-2,4-diones, pyridines and pyrido[2,3-d]pyrimidines and the generation of secondary alkylamines by borane reduction. S.S.Rahman et al. reported on the FT-IR and Raman spectroscopic monitoring of reactions on a single SASRIN™ bead and C.L.Brummel et al. on the evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. For a review on the manifold applications of our SASRIN™ resin, including many useful procedures, please ask for our SASRIN™ brochure. Bachem offers a large variety of Fmoc-amino acids linked to SASRIN™ resin. See also D-2440.
Catalog Number D-1295
Synonyms 3-CH₃O-4-HOCH₂-Ph-O-CH₂-Ph-polymer
CAS Registry Number 124760-64-1
Storage Conditions +5 ± 3 °C
Links / Documents:
Brochures:

Bachem product citations

O.Vadas et al., Biopolymers, 90, 496 (2008)
R.L.Stafford and P.B.Dervan, J. Am. Chem. Soc., 129, 14026 (2007)
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J.W.Thuring et al., Biochemistry, 41, 2002 (2002)
M.C.de Jong et al., Cancer Res., 61, 2552 (2001)
K.Paulvannan and T.Chen, J. Org. Chem., 65, 6160 (2000)
A.A.Profit et al., J. Am. Chem. Soc., 121, 280 (1999)
C.L.Brummel et al., Anal. Chem., 68, 237 (1996)
S.Vuilleumier and M.Mutter, Biopolymers, 33, 389 (1993)

Product citations

M.Mergler et al., Chimia, 53, 29 (1999)
S.S.Rahmann et al., J. Org. Chem., 63, 6196 (1998)
B.Ruhland et al., J. Org. Chem., 62, 7820 (1997)
M.F.Gordeev et al., Tetrahedron Lett., 38, 1729 (1997)
C.L.Brummel et al., Anal. Chem., 68, 237 (1996)
M.Mergler et al., Peptides, Chemistry and Biology, Proceedings of the 10th American Peptide Symposium, St. Louis, p. 259, G.R.Marshall, ed., Escom, Leiden, (1988)
M.Mergler et al., Tetrahedron Lett., 29, 4005 (1988)
M.Mergler et al., Tetrahedron Lett., 29, 4009 (1988)