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Details
A strong antioxidant and a cysteine prodrug. OTC, a 5-oxoproline analog, is metabolized by 5-oxoprolinase and converted to cysteine, the rate-limiting amino acid for glutathione synthesis. It may therefore be useful in restoring depleted glutathione stores in HIV-1-infected persons, which may in turn inhibit the progression of HIV disease.
Q-1535 may be inserted in place of Pyr. The chemical behaviour of OTC was studied by MacLaren. OTC was employed in the total synthesis of Latrunculin A.
Q-1535 may be inserted in place of Pyr. The chemical behaviour of OTC was studied by MacLaren. OTC was employed in the total synthesis of Latrunculin A.
Catalog Number
Q-1535
Synonyms
OTC, Procysteine, OTZ, L-Thiazolidin-2-one-4-carboxylic acid
Molecular Formula
C₄H₅NO₃S
Relative Molecular Mass
147.16
CAS Registry Number
[19771-63-2]
Storage Conditions
+5 ± 3 °C
Areas of Interest
Infectious Disease
Links / Documents:
Product citations
J.D.White and M.Kawasaki,
J. Org. Chem.,
57,
5292 (1992)
J.A.McLaren,
Aust. J. Chem.,
21,
1891 (1968)
