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Details
The pentapeptide YIGSR located within domain III of the laminin B1 chain, represents a major receptor binding site in laminin. By competing with laminin for the cell surface receptor, the short peptide is able to inhibit cell attachment to basement membranes, thus preventing the formation of tumor metastases. YIGSR also promotes tumor cell migration and, moreover, mediates the adhesion of a variety of epithelial cells to laminin.
Catalog Number
H-6825
APC Number
44-0-37
One Letter Code
YIGSR
Synonyms
Laminin β-1 Chain (929-933) (human, mouse), YIGSR, Laminin Fragment (929-933)
Molecular Formula
C₂₆H₄₂N₈O₈
Relative Molecular Mass
594.67
CAS Registry Number
[110590-64-2] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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