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4010438

Availability: In stock

DL-Thiorphan
((RS)-2-Benzyl-3-mercaptopropionyl)-Gly-OH

4010438

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4010438.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 263.00
CHF 244.59 (7%)
4010438.0100 100 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 788.00
CHF 732.84 (7%)

Details

Potent and specific inhibitor of neprilysin with antinociceptive activity. Thiorphan is cleaved by peptidylglycine α-amidating monooxygenase yielding 2-benzyl-3-mercaptopropionamide.
Catalog Number N-1195
Synonyms (DL-3-Mercapto-2-benzylpropanoyl)-Gly-OH
Molecular Formula C₁₂H₁₅NO₃S
Relative Molecular Mass 253.32
CAS Registry Number 76721-89-6
Storage Conditions -20 ± 5 °C
Keywords Neprilysin inhibitor
Links / Documents:
Brochures:

Bachem product citations

S.Meini et al., Eur. J. Pharmacol., 635, 34 (2010)
F.Bellucci et al., Br. J. Pharmacol., 158, 1996 (2009)
C.Cialdai et al., Eur. J. Pharmacol., 549, 140 (2006)
N.R.McIntyre et al., FEBS Lett., 580, 521 (2006)
P.Cucchi et al., Eur. J. Pharmacol., 528, 7 (2005)
G.O.Dussor et al., Eur. J. Neurosci., 18, 2515 (2003)
A.M.Elhassan et al., Brain Res., 879, 23 (2000)
S.Meini et al., Eur. J. Pharmacol., 388, 177 (2000)
S.Meini et al., Eur. J. Pharmacol., 409, 185 (2000)

Product citations

D.N.McIntyre et al., FEBS Lett., 580, 521 (2006)
C.Schmid et al., Regul. Pept., 130, 57 (2005)
I.Dolev and D.M.Michaelson, Proc. Natl. Acad. Sci. USA, 101, 13909 (2004)
B.P.Roques and A.Beaumont, Trends Pharmacol. Sci., 11, 245 (1990)
D.A.Evans et al., J. Org. Chem., 50, 1830 (1985)
B.P.Roques et al., Life Sci., 31, 1749 (1982)
B.P.Roques et al., Nature, 288, 286 (1980)

4010438

Enzyme Substrates Inhibitors
Membrane Metalloendopeptidase    
Neprilysin