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Availability: In stock

4-Hydroxymethyl-benzoic acid


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4009594.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 105.00
CHF 97.65 (7%)
4009594.0025 25 g Ships within 3-5 business days  
CHF 420.00
CHF 390.60 (7%)


This linker for SPPS is essentially acid-stable. HMBA is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides. Ammonolysis under high pressure is an especially convenient cleavage method for obtaining ibraries of peptide amides. Peptides containing a removable solubilizing C-terminal arginine tags can be obtained by insertion of a HMBA moiety.
Catalog Number Q-1185
Synonyms HMBA
Molecular Formula C₈H₈O₃
Relative Molecular Mass 152.15
CAS Registry Number 3006-96-0
Storage Conditions +5 ± 3 °C

Product citations

P.W.R.Harris and M.A.Brimble, Synthesis, 3460 (2009)
E.Atherton et al., J. Chem. Soc. Perkin Trans. I, 538 (1981)