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Details
BCM-7, YPFPGPI, has first been isolated from an enzymatic casein digest. Only cow casein variants A1 and B yield this bioactive peptide after in vitro digestion with intestinal enzymes, but not the common A2 variant. β-Casomorphin displays opioid properties. The β-casomorphin generated by digestion of bovine milk could play a role in the aetiology of human diseases as type 1 diabetes and cardiovascular affections. In a rat model, BCM-7 attenuated the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells.
Catalog Number
H-2280
APC Number
24-3-10
One Letter Code
YPFPGPI
Synonyms
β-Casomorphin-7 (bovine), β-Casomorphin (1-7), bovine
Molecular Formula
C₄₁H₅₅N₇O₉
Relative Molecular Mass
789.93
CAS Registry Number
[72122-62-4]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Opioid peptide
Areas of Interest
Opioid Research
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Bachem product citations
I.De Noni and S.Cattaneo,
Food Chem.,
119,
560 (2010)
