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Availability: In stock

4-Hydroxymethyl-benzoic acid

Q-1185

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
Q-1185.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 103.00
CHF 95.79 (7%)
Q-1185.0025 25 g Ships within 3-5 business days  
CHF 412.00
CHF 383.16 (7%)
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Details

This linker for SPPS is essentially acid-stable. HMBA is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides. Ammonolysis under high pressure is an especially convenient cleavage method for obtaining ibraries of peptide amides. Peptides containing a removable solubilizing C-terminal arginine tags can be obtained by insertion of a HMBA moiety.
Item Number 4009594
Synonyms HMBA
Molecular Formula C₈H₈O₃
Relative Molecular Mass 152.15
CAS Registry Number [3006-96-0]
Storage Conditions +5 ± 3 °C

Product citations

P.W.R.Harris and M.A.Brimble, Synthesis, 3460 (2009)
E.Atherton et al., J. Chem. Soc. Perkin Trans. I, 538 (1981)