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Sarafotoxins have been purified and sequenced from the venom of the Israeli snake Atractaspis engaddensis. The sarafotoxins, which cause severe coronary vasospasm in snakebite victims, exhibit a remarkable structural and functional homology to the endothelin family. They bind with high affinity to rat atrial and brain membranes and induce the hydrolysis of phosphoinositides in these tissues.

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