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N-1975

Availability: In stock

Z-Leu-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone

N-1975

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1975.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 263.00
CHF 244.59 (7%)
N-1975.0005 5 mg Ships within 3-5 business days  
CHF 1,051.00
CHF 977.43 (7%)
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Details

Cell permeable caspase-8 inhibitor. The O-methyl groups serve to enhance the cell membrane permeability. Within the cell this inhibitor is converted to its biological active form Z-LETD-FMK by endogenous esterases which hydrolyze the O-methyl groups.
Item Number 4042558
Synonyms Z-LE(OMe)TD(OMe)-FMK
Molecular Formula C₃₀H₄₃FN₄O₁₁
Relative Molecular Mass 654.69
CAS Registry Number [1926163-60-1]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Cell permeable caspase-8 inhibitor
Areas of Interest Apoptosis & Necrosis
Links / Documents:
Brochures:

Bachem product citations

Y.J.Park et al., Diabetologia, 57, 765 (2014)

Product citations

B.A.McLaughlin et al., J. Neurosci., 21, 3303 (2001)
M.Ahmad and Y.Shi, Oncogene, 19, 3363 (2000)

N-1975

Enzyme Substrates Inhibitors
Caspase-8 (MACH; FLICE; Mch5)