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Availability: In stock

H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Val-Glu-Phe-Gly-Gly-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-OH trifluoroacetate salt

N-1920

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1920.0500 0.5 mg Ships within 3-5 business days  
CHF 670.00
CHF 623.10 (7%)
N-1920.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'133.00
CHF 1'053.69 (7%)
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Details

A memapsin-2 (β-secretase) inhibitor consisting of the transition-state inhibitor of memapsin-2, OM00-3, (Ki = 0.31 nM) covalently linked to a nine-residue poly D-arginine carrier protein. [OM00-3]r₉ (ELDLpsi[CHOH-CH₂]AVEFGGr₉) was shown to penetrate the plasma membrane of cultured cells and to inhibit production of amyloid β-protein. In transgenic Tg2576 mice with amyloid plaque pathology intraperitoneal injection of N-1920 resulted in a significant decrease in amyloid β-protein levels in plasma and brain.
Item Number 4047413
Synonyms [OM00-3]r₉, [OM00-3]DR₉
Molecular Formula C₁₀₂H₁₈₃N₄₅O₂₆
Relative Molecular Mass 2455.86
CAS Registry Number [527674-72-2] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

N-1920

Enzyme Substrates Inhibitors
β-Secretase