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Availability: In stock

Calpain Inhibitor VI
4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde

N-1855

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1855.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 185.00
CHF 172.05 (7%)
N-1855.0005 5 mg Ships within 3-5 business days  
CHF 742.00
CHF 690.06 (7%)
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Details

4-Fluorobenzenesulfonyl-VL-CHO is a potent inhibitor of calpain I and II (IC₅₀ = 7.5 nM and 78 nM, respectively) but also of cathepsin B (IC₅₀ = 15 nM) and cathepsin L (IC₅₀ = 1.5 nM). The IC₅₀ values for other proteases such as interleukin 1β-converting enzyme, thrombin, factor VIIa, trypsin and chymotrypsin were above 100 µM.
Item Number 4043024
Synonyms SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
Molecular Formula C₁₇H₂₅FN₂O₄S
Relative Molecular Mass 372.46
CAS Registry Number [190274-53-4]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Calpain and cathepsin inhibitor

N-1855

Enzyme Substrates Inhibitors
Calpain    
Cathepsin L    
Cathepsin B