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Availability: In stock

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

N-1650

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1650.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 134.00
CHF 124.62 (7%)
N-1650.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 536.00
CHF 498.48 (7%)
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Details

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease.
E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro.
By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer's disease animal models.
Item Number 4027911
Synonyms E-64d, Aloxistatin, Loxistatin, EP453, L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide
Molecular Formula C₁₇H₃₀N₂O₅
Relative Molecular Mass 342.44
CAS Registry Number [88321-09-9]
Storage Conditions -20 ± 5 °C
Keywords Cell-permeable Cys proteinase inhibitor
Areas of Interest Alzheimer's Disease

N-1650

Enzyme Substrates Inhibitors
Cathepsin H    
Calpain    
Cathepsin D    
Cathepsin L    
Calpain-2    
Cathepsin B