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Availability: In stock

Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

N-1630

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1630.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 247.00
CHF 229.71 (7%)
N-1630.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 989.00
CHF 919.77 (7%)
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Details

Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
Item Number 4027878
APC Number 81-7-15
Synonyms Ac-WEHD-CHO
Molecular Formula C₂₈H₃₃N₇O₉
Relative Molecular Mass 611.61
CAS Registry Number [189275-71-6]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords ICE inhibitor
Areas of Interest Apoptosis & Necrosis

N-1630

Enzyme Substrates Inhibitors
Caspase-4 (TX; ICH-2; ICErel-II)    
Caspase-8 (MACH; FLICE; Mch5)    
Caspase-1 (ICE)    
Caspase-5 (TY; ICErel-III)