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Availability: In stock

Z-Val-Ala-DL-Asp-fluoromethylketone

N-1510

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1510.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 309.00
CHF 287.37 (7%)
N-1510.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'236.00
CHF 1'149.48 (7%)
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Details

zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis.
Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560,
Inhibitor of peptide:N-glycanase (PNGase).
Item Number 4026865
Synonyms Z-VAD-FMK
Molecular Formula C₂₁H₂₈FN₃O₇
Relative Molecular Mass 453.47
CAS Registry Number [220644-02-0]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Pan-caspase inhibitor
Areas of Interest Apoptosis & Necrosis

Bachem product citations

S.B.Berger et al., Cell Death Discov., 1, 15009 (2015)
M.S.I.Abaza, Exp. Ther. Med, 1, 675 (2010)

N-1510

Enzyme Substrates Inhibitors
Caspase-1 (ICE)    
Peptide-N4-(N-Acetyl-β-glucosaminyl)asparagine Amidase (PNGase)