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H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH trifluoroacetate salt

N-1390

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1390.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 453.00
CHF 421.29 (7%)
N-1390.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'813.00
CHF 1'686.09 (7%)
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Details

B581, Cys-psi(CH₂NH)-Val- psi[CH₂NH]-Phe-Met is a farnesyltransferase (FTase) inhibitor of special stability and membrane permeability. Due to its high selectivity, B581 is more than 30-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase). Inhibitors of the farnesyltransferase are potential candidates for the development of anticancer drugs.
Item Number 4025336
APC Number 91-1-29
Synonyms B581, Farnesyltransferase inhibitor, N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-Phe-Met-OH
Molecular Formula C₂₂H₃₈N₄O₃S₂
Relative Molecular Mass 470.70
CAS Registry Number [149759-96-6] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cancer Research

N-1390

Enzyme Substrates Inhibitors
Farnesyl-Diphosphate Farnesyltransferase