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Availability: In stock

Angiotensin I-Converting Enzyme (ACE) Inactivator
Cyanoac-Phe-Phe-OH

N-1360

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1360.0250 250 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 464.00
CHF 431.52 (7%)
N-1360.1000 1 g Ships within 3-5 business days  
CHF 1'391.00
CHF 1'293.63 (7%)
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Details

ACE-mediated deprotonation of cyanoacetyl-Phe-Phe leads to the formation of a ketenimine intermediate. This reactive intermediate, in turn, traps an active-site nucleophile to irreversibly inactivate the enzyme. This principle therefore seems to be suitable for the development of irreversible inactivators of therapeutically important zinc metalloproteases.
Item Number 4019609
APC Number 12-1-19
Molecular Formula C₂₁H₂₁N₃O₄
Relative Molecular Mass 379.42
CAS Registry Number [144085-32-5]
Source Synthetic
Storage Conditions -20 ± 5 °C

N-1360

Enzyme Substrates Inhibitors
Peptidyl-Dipeptidase A    
Angiotensin I-Converting Enzyme (ACE)