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Angiotensin I-Converting Enzyme (ACE) Inactivator


Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
N-1360.0250 250 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 473.00
CHF 439.89 (7%)
N-1360.1000 1 g Ships within 3-5 business days  
CHF 1,419.00
CHF 1,319.67 (7%)
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ACE-mediated deprotonation of cyanoacetyl-Phe-Phe leads to the formation of a ketenimine intermediate. This reactive intermediate, in turn, traps an active-site nucleophile to irreversibly inactivate the enzyme. This principle therefore seems to be suitable for the development of irreversible inactivators of therapeutically important zinc metalloproteases.
Item Number 4019609
APC Number 12-1-19
Molecular Formula C₂₁H₂₁N₃O₄
Relative Molecular Mass 379.42
CAS Registry Number [144085-32-5]
Source Synthetic
Storage Conditions -20 ± 5 °C


Enzyme Substrates Inhibitors
Peptidyl-Dipeptidase A    
Angiotensin I-Converting Enzyme (ACE)