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Lys(Dabsyl)-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Gln-Lucifer Yellow ammonium salt
H-Lys(Dabsyl)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gln-Lucifer Yellow ammonium salt

M-2570

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
M-2570.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 618.00
CHF 574.74 (7%)
M-2570.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'030.00
CHF 957.90 (7%)
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Details

A highly selective substrate for measuring BACE1 (Km = 9 µM, kcat = 0.02 s⁻¹) and BACE2 activity. In this fluorescence resonance energy transfer (FRET) substrate the fluorescent group Lucifer Yellow is efficiently quenched by Dabsyl (4-(4-Dimethylaminophenylazo)benzenesulfonyl). Enzymatic cleavage can be assayed by detecting the increase in fluorescence emission at 520 nm using an excitation wavelength of 430 nm.
Item Number 4046866
Synonyms Lys(Dabsyl)-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Gln-Lucifer Yellow
Molecular Formula C₈₉H₁₂₂N₂₄O₃₁S₃
Relative Molecular Mass 2120.29
CAS Registry Number [1802078-42-7] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

M-2570

Enzyme Substrates Inhibitors
β-Secretase